December 3, 1997

GENERAL SURGICAL INNOVATIONS SIGNS WORLDWIDE DISTRIBUTION AGREEMENT WITH GENZYME SURGICAL PRODUCTS CORPORATION

Cupertino, CA, December 3, 1997 --General Surgical Innovations, Inc. (GSI) (Nasdaq NM: GSII today announced that it has entered into an exclusive four-year agreement with the Genzyme Surgical Products Corporation (Nasdaq NM: GENZ). Under the agreement, Genzyme, a biotechnology and health care products company, has exclusive rights to market and distribute GSI?s surgical balloon dissectors worldwide for use in plastic surgery (reconstructive and aesthetic) procedures. While the first product to be distributed is GSI?s SPACEMAKER® Breast Balloon Dissector for use in breast reconstruction and augmentation surgeries, the agreement also provides for GSI and Genzyme to jointly pursue additional plastic surgery procedures such as abdominoplasty or face lift procedures. Further terms of the agreement have not been disclosed.

GSI?s SPACEMAKER Breast Balloon Dissector systems provide an alternative to the type of blunt dissection used in conventional open surgery or minimally invasive surgery conducted outside of a natural body cavity. Common to all procedures using GSI?s SPACEMAKER balloon dissectors, the balloon is inserted uninflated between tissue layers through a small incision. The balloon is then filled to a specific volume with air or saline, causing the desired dissection of the tissue planes. The balloon is then deflated, removed and the dissected space can be held open with a mechanical retraction device or inflated with gas to enable a minimally invasive procedure. Because the SPACEMAKER Breast Balloon Dissector is inserted through a small incision where it gently and quickly creates a predictable pocket for insertion of a breast implant, patient discomfort and scarring can be reduced. Worldwide, over 200,000 breast reconstruction and augmentation surgeries are performed annually.

"We are excited about signing this agreement with Genzyme and the growth potential it brings to GSI as we continue to strengthen our distribution network and expand our presence in the plastic surgery market," stated Gregory D. Casciaro, President and Chief Operating Officer of GSI. "The Company recently formed a Technology Alliance Group to consider strategic partnering opportunities. This agreement is a direct result of the group?s efforts and our commitment to establishing partners to distribute our technology in the U.S. and abroad."

Headquartered in Cupertino, California, General Surgical Innovations, Inc. develops, manufactures, and sells balloon dissection systems for minimally invasive surgery. The Company?s products are specifically designed for use with endoscopic and laparoscopic techniques in general, cardiovascular, cosmetic and reconstructive surgeries to create a working space at the surgical site, minimize tissue damage and improve patient recovery. The Company has developed a broad range of balloon shapes and sizes to be used for various surgical techniques, procedures, and market segments. In addition to selling products through distributors, GSI also sells products directly into the cardiovascular surgery market.

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